| 龚跃法 |
| 所属地区 |
中国 |
|
| 所属行业 |
未知 |
| 所属专业 |
未知 |
| 所属分类 |
高等院校 |
| 个人基本信息 |
| 性别 |
未知 |
出生年月 |
1964年09月 |
| 职称 |
教授 |
学历 |
博士 |
| 研究领域 |
生物催化有机合成反应、仿生催化反应、酶与细胞的固定化技术、医药中间体的合成、含氟生物活性物质的研制等 |
| 毕业院校 |
中科院上海有机化学研究 |
| 工作单位 |
华中科技大学化学与化工学院 |
| 个人简介 |
教育与研究经历
1979-1983年在杭州大学化学系学习，获学士学位。1983-1988年在中科院上海有机化学研究所学习，从事有机化学专业方面的研究工作，获得理学硕士及理学博士学位。
1988年底至今一直在华中科技大学化学系工作。期间1990-1992年在日本筑波大学化学系做博士后研究。1998-2002年以日本通产省特别研究员身份在日本工业技术院名古屋工业研究所做访问研究。
研究领域与兴趣
科研领域：物理有机化学、自由基化学、有机氟化学、有机合成、生物催化
在研领域：生物催化有机合成反应、仿生催化反应、酶与细胞的固定化技术、医药中间体的合成、含氟生物活性物质的研制等
主要研究技术：
1）含氟酮、醇和胺的合成技术
2）含氟植物生长调节剂的合成技术
3）含氟有机硅的合成技术
4）有机无机复合纳米孔径材料的研制技术
5）生物催化合成手性醇、胺的技术
教学情况
在华中科技大学化学系工作期间，先后承担了本科生的《有机化学》、《有机化学实验》、《有机合成》和《有机波谱学》等课程的教学；以及研究生的《高等有机化学》、《有机金属化学》、《生物有机化学》和《高等有机化学实验》等课程的教学。
代表性成果
教材专著：《有机化学习题祥解》、《合成化学》等
发表论文：
1) Lu, Dengfu; Li, Yajun; Gong, Yuefa. Organocatalytic Asymmetric Tandem Michael Addition-Hemiacetalization: A Route to Chiral Dihydrocoumarins, Chromanes, and 4H-Chromenes. Journal of Organic Chemistry (2010), 75(20), 6900-6907. CODEN: JOCEAH ISSN:0022-3263. AN 2010:1186258 CAPLUS
2) Chen, Zixian; Zhu, Jiangtao; Xie, Haibo; Li, Shan; Wu, Yongming; Gong, Yuefa. A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C-F Bond Cleavage Protocol. Organic Letters (2010), 12(19), 4376-4379. CODEN: ORLEF7 ISSN:1523-7060. AN 2010:1116328 CAPLUS
3) Chen, Zixian; Zhu, Jiangtao; Xie, Haibo; Li, Shan; Wu, Yongming; Gong, Yuefa. A novel method for the synthesis of 2-trifluoromethylindoles from N-(o-haloaryl)alkynylimines. Synlett (2010), (9), 1418-1420. CODEN: SYNLES ISSN:0936-5214. CAN 153:286796 AN 2010:882237 CAPLUS
4) Chen, Zixian; Zhu, Jiangtao; Xie, Haibo; Li, Shan; Wu, Yongming; Gong, Yuefa. Copper(I)-Catalyzed Synthesis of Novel 4-(Trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxalines via Cascade Reactions of N-(o-Haloaryl)alkynylimine with Sodium Azide. Advanced Synthesis & Catalysis (2010), 352(8), 1296-1300. CODEN: ASCAF7 ISSN:1615-4150. CAN 153:204302 AN 2010:658455 CAPLUS
5) Lu, Dengfu; Gong, Yuefa; Wang, Weizhou. Prolylprolinol-Catalyzed Asymmetric Michael Addition of Aliphatic Aldehydes to Nitroalkenes. Advanced Synthesis & Catalysis (2010), 352(4), 644-650. CODEN: ASCAF7 ISSN:1615-4150. CAN 153:358799 AN 2010:350824 CAPLUS
6) Chen, Zixian; Zhu, Jiangtao; Xie, Haibo; Li, Shan; Wu, Yongming; Gong, Yuefa. Palladium catalyzed synthesis of 2-trifluoromethylquinolines through a domino Sonogashira-alkyne carbocyclization process. Chemical Communications (Cambridge, United Kingdom) (2010), 46(12), 2145-2147. CODEN: CHCOFS ISSN:1359-7345. CAN 152:501156 AN 2010:300431 CAPLUS
7) Luo, Fan; Wang, Ping; Gong, Yuefa. Highly enantioselective bioreduction of 2-fluorocinnamyl alcohols mediated by Saccharomyces cerevisiae. Tetrahedron Letters (2010), 51(13), 1693-1695. CODEN: TELEAY ISSN:0040-4039. CAN 152:475714 AN 2010:256710 CAPLUS
8) Zhang, Fang-Lin; Xu, Ai-Wen; Gong, Yue-Fa; Wei, Mo-Hui; Yang, Xiang-Liang. Asymmetric Organocatalytic Four-Component Quadruple Domino Reaction Initiated by Oxa-Michael Addition of Alcohols to Acrolein. Chemistry--A European Journal (2009), 15(28), 6815-6818, S6815/1-S6815/61. CODEN: CEUJED ISSN:0947-6539. CAN 151:336767 AN 2009:849423 CAPLUS
9) Zhang, Fanglin; Peng, Yiyuan; Gong, Yuefa. Asymmetric synthesis of bicyclic piperidines via L-proline catalyzed aldol reaction of 3-phthalimidopropanal. Chirality (2008), 20(6), 805-811. CODEN: CHRLEP ISSN:0899-0042. CAN 149:267886 AN 2008:747979 CAPLUS
10) Zhao, Yuling; Lu, Naihao; Li, Hailing; Zhang, Yan; Gao, Zhonghong; Gong, Yuefa. High glucose induced human umbilical vein endothelial cell injury: involvement of protein tyrosine nitration. Molecular and Cellular Biochemistry (2008), 311(1&2), 19-29. CODEN: MCBIB8 ISSN:0300-8177. CAN 148:582791 AN 2008:345252 CAPLUS
11) Zhang, Fanglin; Peng, Yiyuan; Liao, Saihu; Gong, Yuefa. Pyrrolidine as an efficient organocatalyst for direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones. Tetrahedron (2007), 63(22), 4636-4641. CODEN: TETRAB ISSN:0040-4020. CAN 147:95136 AN 2007:477915 CAPLUS
12) Li, Ning; Zhang, Fanglin; Gong, Yuefa. Highly stereoselective bioreduction and one-way isomerization of 2-alkyl-4,4,4-trichloro-2-butenals. Tetrahedron Letters (2007), 48(11), 1895-1898. CODEN: TELEAY ISSN:0040-4039. CAN 146:421624 AN 2007:187822 CAPLUS
13) Zhang, Fanglin; Su, Ning; Gong, Yuefa. Highly selective catalytic cross-aldol reactions of chloral with aliphatic aldehydes. Synlett (2006), (11), 1703-1706. CODEN: SYNLES ISSN:0936-5214. CAN 145:418651 AN 2006:846743 CAPLUS
14) Zhao, Yuling; Li, Hailing; Gao, Zhonghong; Gong, Yuefa; Xu, Huibi. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. European Journal of Pharmacology (2006), 536(1-2), 192-199. CODEN: EJPHAZ ISSN:0014-2999. CAN 144:404140 AN 2006:362017 CAPLUS
15) Zeng, Li; Luo, Kaikun; Gong, Yuefa. Preparation and characterization of dendritic composite magnetic particles as a novel enzyme immobilization carrier. Journal of Molecular Catalysis B: Enzymatic (2006), 38(1), 24-30. CODEN: JMCEF8 ISSN:1381-1177. CAN 144:329825 AN 2006:21867 CAPLUS
16) Huang, Yikang; Zhang, Fanglin; Gong, Yuefa. A convenient approach to (S)-2-ethylhexan-1-ol mediated by Bakers yeast. Tetrahedron Letters (2005), 46(42), 7217-7219. CODEN: TELEAY ISSN:0040-4039. CAN 143:325964 AN 2005:1008991 CAPLUS
17) Gong, Yuefa; Kato, Katsuya. Recent applications of trifluoroacetaldehyde ethyl hemiacetal for the synthesis of trifluoromethylated compounds. Current Organic Chemistry (2004), 8(17), 1659-1675. CODEN: CORCFE ISSN:1385-2728. CAN 142:260976 AN 2004:849009 CAPLUS
18) Gong, Yuefa; Kato, Katsuya. New synthesis of 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones. Journal of Fluorine Chemistry (2004), 125(5), 767-773. CODEN: JFLCAR ISSN:0022-1139. CAN 141:332025 AN 2004:385361 CAPLUS
19) Kato, Katsuya; Gong, Yuefa; Saito, Takao; Yokogawa, Yoshiyuki. Enzymatic resolution of 2,2,2-trifluoro-1-arylethylamine derivatives by Pseudomonas fluorescens lipase in organic solvents. Journal of Molecular Catalysis B: Enzymatic (2004), 30(2), 61-68. CODEN: JMCEF8 ISSN:1381-1177. CAN 141:331774 AN 2004:384044 CAPLUS
19) Gong, Yuefa; Kato, Katsuya. Nucleophilic replacement of p-(1-chloro-2,2,2-trifluoroethyl)phenols: novel synthesis of -trifluoromethyl-tyrosine. Journal of Fluorine Chemistry (2003), 121(2), 141-146. CODEN: JFLCAR ISSN:0022-1139. CAN 140:42430 AN 2003:364233 CAPLUS
20) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. BF3-promoted aromatic substitution of N-alkyl -trifluoromethylated imine: facile synthesis of 1-aryl-2,2,2-trifluoroethylamines. Bulletin of the Chemical Society of Japan (2002), 75(12), 2637-2645. CODEN: BCSJA8 ISSN:0009-2673. CAN 138:320884 AN 2002:974638 CAPLUS
21) Kato, Katsuya; Gong, Yuefa; Irimescu, Roxana; Saito, Takao; Yokogawa, Yoshiyuki. Resolution of 4-(1-hydroxy-2,2,2-trifluoroethyl)phenol and its derivatives by lipase-catalyzed enantioselective alcoholysis. Biotechnology Letters (2002), 24(19), 1623-1630. CODEN: BILED3 ISSN:0141-5492. CAN 138:88729 AN 2002:730115 CAPLUS
22) Gong, Yuefa; Kato, Katsuya. Convenient synthesis of -trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl -trifluoroacetaldehyde hemiaminal. Journal of Fluorine Chemistry (2002), 116(2), 103-107. CODEN: JFLCAR ISSN:0022-1139. CAN 138:169830 AN 2002:651295 CAPLUS
23) Gong, Yuefa; Kato, Katsuya. Facile synthesis of o- and p-(1-trifluoromethyl)-alkylated phenols via generation and reaction of quinone methides. Synlett (2002), (3), 431-434. CODEN: SYNLES ISSN:0936-5214. CAN 137:78729 AN 2002:209386 CAPLUS
24) Kato, Katsuya; Gong, Yuefa; Saito, Takao; Yokogawa, Yoshiyuki. Preparation and catalytic performance of lipases encapsulated in sol-gel materials. Bioscience, Biotechnology, and Biochemistry (2002), 66(1), 221-223. CODEN: BBBIEJ ISSN:0916-8451. CAN 136:308562 AN 2002:120705 CAPLUS
25) Kato, Katsuya; Gong, Yuefa; Saito, Takao; Yokogawa, Yoshiyuki. Regio- and enantio-selective acetylation of 3,3,3-trifluoro-2-arylpropane-1,2-diols using Candida antarctica lipase. Biotechnology Letters (2001), 23(21), 1729-1734. CODEN: BILED3 ISSN:0141-5492. CAN 136:278908 AN 2001:879854 CAPLUS
26) Gong, Yuefa; Kato, Katsuya. Diastereoselective Friedel-Crafts reaction of -trifluoromethyl imines derived from chiral amines. Tetrahedron: Asymmetry (2001), 12(15), 2121-2127. CODEN: TASYE3 ISSN:0957-4166. CAN 136:216600 AN 2001:755146 CAPLUS
27) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. Regioselective Substitution of Phenols with Trifluoroacetaldehyde Ethyl Hemiacetal. Bulletin of the Chemical Society of Japan (2001), 74(2), 377-383. CODEN: BCSJA8 ISSN:0009-2673. CAN 135:19408 AN 2001:233163 CAPLUS
28) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal. Journal of Heterocyclic Chemistry (2001), 38(1), 25-28. CODEN: JHTCAD ISSN:0022-152X. CAN 135:46071 AN 2001:223196 CAPLUS
29) Kato, K.; Gong, Y.-f.; Tanaka, S.; Katayama, M.; Kimoto, H. Lipase-catalyzed optical resolution of trifluoro(aryl)ethanols. Journal of Molecular Catalysis B: Enzymatic (2001), 11(4-6), 287-294. CODEN: JMCEF8 ISSN:1381-1177. CAN 134:309786 AN 2001:93066 CAPLUS
30) Kato, Katsuya; Gong, Yuefa; Saito, Takao; Kimoto, Hiroshi. Convenient synthesis of optically active 2,2,2-trifluoro-1-phenylethylamine. Enantiomer (2000), 5(5), 521-524. CODEN: EANTE2 ISSN:1024-2430. CAN 134:178302 AN 2000:872172 CAPLUS
31) Kato, Katsuya; Gong, Yuefa; Saito, Takao; Kimoto, Hiroshi. Efficient preparation of optically active ketoprofen by Mucor javanicus lipase immobilized on an inorganic support. Journal of Bioscience and Bioengineering (2000), 90(3), 332-334. CODEN: JBBIF6 ISSN:1389-1723. CAN 134:114871 AN 2000:813008 CAPLUS
32) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. Crystal structure of N-acetyl- -trifluoromethyltryptophan ethyl acetate. Analytical Sciences (2000), 16(8), 893-894. CODEN: ANSCEN ISSN:0910-6340. CAN 133:289091 AN 2000:618413 CAPLUS
33) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. Friedel-Crafts reaction of N-alkyl trifluoroacetaldehyde imine: facile synthesis of 1-aryl-2,2,2-trifluoroethylamines. Synlett (2000), (7), 1058-1060. CODEN: SYNLES ISSN:0936-5214. CAN 133:237778 AN 2000:521094 CAPLUS
34) Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi. Substitution of five-membered heteroarenes and uracils with trifluoroacetaldehyde ethyl hemiacetal. Bulletin of the Chemical Society of Japan (2000), 73(1), 249-250. CODEN: BCSJA8 ISSN:0009-2673. CAN 132:222505 AN 2000:97661 CAPLUS
获奖与荣誉
《单电子转移反应的化学及顺磁共振研究》获国家教委科技进步二等奖(甲类) ，1993。
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